SPC-flakes

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265917/

https://www.ncbi.nlm.nih.gov/pubmed/32523900?dopt=Abstract

Dietary Restriction for The Treatment of Meniere’s Disease.

Transl Med UniSa. 2020 May;22:5-9

Authors: De Luca P, Cassandro C, Ralli M, Gioacchini FM, Turchetta R, Orlando MP, Iaccarino I, Cavaliere M, Cassandro E, Scarpa A

Abstract

Meniere’s disease (MD) is an idiopathic inner ear disorder characterized by spontaneous recurrent vertigo, fluctuating sensorineural hearing loss (SNHL), aural fullness and tinnitus. Endolymphatic hydrops (EH) of the inner ear is currently considered the pathophysiological mechanisms that underlies typical symptoms of MD. MD diagnosis is based on the criteria of the Baràny Society. There are many therapeutic options for MD, but none is considered effective by the scientific community. The first-line treatment commonly includes dietary modification, as low salt diet and reduction of alcohol and caffeine daily intake. Although some studies showed a positive effect of these dietary restrictions, even in the prevention of recurrences, currently there is no uniform consensus on their usefulness. New dietary approach, such SPC-flakes, are being evaluated: further assessments will be needed to validate their use in clinical practice.

E. Specially processed cereals (SPC)
Recently, the intake of antisecretory factor (AF)-inducing specially processed cereals (SPC)-flakes has been proposed as complementary therapy for Meniere’s disease.

Antisecretory factor (AF) is a 41 kDa protein originally isolated due to its ability to inhibit experimental diarrhoea; the specific effect of endogenous AF is not completely understood, but it seems to modulate water and ion transport.

The intake of specially processed cereals (SPC-flakes) results in an increase of AF activity in plasma [56]. Hanner et al hypothesized that an increased AF activity could positively influence the course of MD: their work demonstrated that the intake of SPC-flakes not only significantly reduced vertigo in a half of the patients, but was also related to an increase level of active AF in plasma and positive clinical outcome.

Treatment with SPC appears to be well tolerated by most patients [57] without any complications and, in most of studies, more than half of the study cohort reported subjective improvement in functional level.

On the contrary, Ingvardsen and Klokker [58] observed that antisecretory factor-inducing (AF) SPC were not shown to significantly improve the functional level in patients with MD.

PMID: 32523900 [PubMed]

PubMed:32523900