This page tracks new and upcoming treatment options for Meniere’s disease (MD). What’s in development? What’s promising? What’s available soon? Current topics include SPI-1005, APSLXR, venlafaxine, AM-125, OTO-104 (OTIVIDEX), SLC4A1, antiviral therapy, betahistine, SPT-2101, YPS-201B, CGRP receptor inhibitors (repurposed migraine medications), non-invasive mastoid electric stimulation, and more. Jump to section: News, Research, Clinical Trials
Last updated: 8 months ago
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News
- Clinical severity staging system may aid treatment selection for Meniere disease Sep 6, 2023
- Progress with SPT-2101 for Meniere’s Disease: Encouraging data from the Australian clinical trial Aug 30, 2023
- Two Distinct Patient Groups ID’d in Meniere Disease Aug 10, 2023
- 3D analysis of inner ear provides insights into Ménière’s disease Aug 7, 2023
- Vestibular Function Tests ID Vestibular Migraine Versus Meniere Disease Jul 7, 2023
- Sound Pharma completes enrollment in pivotal Phase 3 clinical trial of SPI-1005 for the treatment of Meniere’s disease involving hearing loss, tinnitus, and dizziness. May 3, 2023
- Otonomy Announces Top-Line Results for the Phase 3 Clinical Trial of OTIVIDEX® in Patients with Ménière’s Disease Feb 22, 2021
- Implant may improve lives of those with serious balance disorder Feb 11, 2021
- Otonomy Completes Patient Enrollment for Phase 3 Trial of OTIVIDEX® in Ménière’s Disease Oct 2, 2020
- Auris Medical Announces Positive Interim Data from TRAVERS Phase 2 Study with AM-125 in Vertigo Sep 3, 2020
- Auris Medical Announces Completion of Enrollment into First Part of TRAVERS Phase 2 Study with AM-125 in Vertigo Jul 29, 2020
- New artificial intelligence technology can read MRI images to diagnose Meniere’s disease Jun 15, 2020
- Otonomy Provides Update on Clinical Trials and Development Programs: Results from Phase 3 trial of OTIVIDEX in Ménière’s disease expected in first quarter of 2021 Jun 15, 2020
- Sound Pharma advances pivotal Phase 3 clinical trials for SPI-1005 in the Treatment of Meniere’s Disease Jun 8, 2020
- Ménière’s disease: New clinical practice guideline to enhance diagnostic accuracy and treatment Apr 8, 2020
- Auris Medical Provides Update on Phase 2 Trial of AM-125 for the Treatment of Acute Peripheral Vertigo Apr 3, 2020
- Auris Medical Provides Update on Ongoing Clinical Trials with Intranasal Betahistine Mar 5, 2020
- Singer Huey Lewis opens up about suicidal thoughts after his Ménière’s disease diagnosis – what is the disorder? Dec 16, 2019
- Successful project to help dizziness sufferers expands to Europe Nov 7, 2019
- FDA grants Fast Track Designation for SPI-1005 in the Treatment of Meniere’s Disease Sep 18, 2019
- Otonomy Expands Recruiting Locations for Phase 3 Study of OTO-104 for the Treatment of Meniere’s Disease Sep 4, 2019
- Auris Medical Announces Randomization of First Patient in AM-125 Phase 2 Trial in Acute Vertigo Jul 30, 2019
- Sound Pharmaceuticals announces positive topline results from the SPI-1005 Phase 2b Meniere’s Disease clinical trial Jun 25, 2019
- Intratympanic mixture gentamicin and dexamethasone vs dexamethasone for unilateral Meniere’s disease Jun 24, 2019
- Sound Pharmaceuticals Completes Phase 2 Study of SPI-1005 for the Treatment of Patients with Meniere’s Disease Jun 18, 2019
- The many treatments for the misery of Ménière’s disease Apr 1, 2019
- Sound Pharmaceuticals announces completion of patient enrollment in Phase 2b clinical trial of SPI-1005 for Meniere’s disease Mar 6, 2019
Research
- Therapeutic Response of Meniere’s Disease Utilizing Sorbus domestica Feb 6, 2024
- Long-term effects of middle ear pressure therapy with the EFET01 device in patients with Ménière’s disease in Japan Jan 5, 2024
- Treatment of Meniere’s disease with simultaneous triple semicircular canal occlusion and cochlear implantation Dec 27, 2023
- Redox Modulation of Meniere Disease by Coriolus Versicolor Treatment, a Nutritional Mushroom Approach with Neuroprotective Potential Dec 11, 2023
- Evaluation of Vestibular Functions in a Case of Vestibular Migraine With Successful Treatment With Erenumab Sep 25, 2023
- Ménière’s disease and allergy: Epidemiology, pathogenesis, and therapy Sep 24, 2023
- Case report: MRI changes of the inner ear in an MD patient with suspected immune dysfunction Sep 7, 2023
- Meniere’s disease: Pathogenesis, treatments, and emerging approaches Aug 28, 2023
- Radiological feature heterogeneity supports etiological diversity among patient groups in Meniere’s disease Jun 26, 2023
- Comparison of clinical characteristics and vestibular function test results in patients with vestibular migraine and Menière’s disease May 16, 2023
- Evaluation of Industry Relationships Among Authors of Systematic Reviews and Meta-analyses Regarding Menieres Disease Oct 12, 2021
- On the Nature of Hearing Loss in Méniere’s Disease: a dramatic recovery of hearing in patients with MD using antiviral (AV) drugs Feb 17, 2021
- Could ionic regulation disorders explain the overlap between meniere’s disease and migraine? Feb 10, 2021
- Aquaporins (AQPs) and diseases pathogenesis: From trivial to undeniable involvements, a disease-based point of view Feb 8, 2021
- Genetics and the Individualized Therapy of Vestibular Disorders Feb 5, 2021
- Pharmacological, Surgical and Diagnostic Innovations in Meniere’s Disease: A Review Dec 31, 2020
- The value of 3D-real IR MRI with intravenous gadolinium injection in the diagnosis of suspected Meniere’s disease in children Nov 12, 2020
- Menière’s disease caused by CGRP – A new hypothesis explaining etiology and pathophysiology Oct 5, 2020
- Effectiveness of Intratympanic Administration of Gentamicin in Unilateral Meniere’s Disease Sep 14, 2020
- Pharmacologic and surgical therapies for patients with Meniere’s disease: A systematic review and network meta-analysis Sep 1, 2020
- The role of endogenous Antisecretory Factor (AF) in the treatment of Ménière’s Disease: A two-year follow-up study Aug 11, 2020
- Nystagmus during an acute Ménière’s attack: from prodrome to recovery Jul 31, 2020
- Live imaging and functional changes of the inner ear in an animal model of Meniere’s disease Jul 23, 2020
- The pharmacological management of vertigo in Meniere disease: summary with evidence from preclinical and clinical studies Jul 15, 2020
- Cochlear Implantation in Patients With Menière’s Disease: Does Disease Activity Affect the Outcome? Jul 14, 2020
- MicroRNA Profiling as a Methodology to Diagnose Ménière’s Disease: Potential Application of Machine Learning Jul 14, 2020
- Intratympanic gentamicin is superior to intratympanic steroids in reducing the number of vertigo attacks in the treatment of Meniere’s disease Jun 25, 2020
- Using betahistine in the treatment of patients with Menière’s disease: a meta-analysis with the current randomized-controlled evidence Jun 25, 2020
- Current status on researches of Meniere’s disease: a review Jun 21, 2020
- Dietary Restriction for The Treatment of Meniere’s Disease May 31, 2020
- Comparison of the video head impulse test results with caloric test in patients with Meniere’s disease and other vestibular disorders May 21, 2020
- Therapeutic role of intravenous glycerol for Meniere’ disease: Preliminary results Apr 21, 2020
- Epidemiology and Seasonal Variation of Ménière’s Disease Apr 14, 2020
- Phonophobia and migraine features in patients with definite meniere’s disease Apr 11, 2020
- Surgical Labyrinthectomy and Cochlear Implantation for the Treatment of Menière’s Disease: results on hearing, vertigo, and tinnitus Apr 10, 2020
- Clinical Practice Guideline: Ménière’s Disease Executive Summary Apr 8, 2020
- Predictive Value of Vestibular Evoked Myogenic Potentials in the Diagnosis of Menière’s Disease and Vestibular Migraine Apr 7, 2020
- OTOG as a Relevant Gene in Familial Meniere’s Disease: the groundwork for genetic testing in MD Apr 2, 2020
- Experimental Animal Models for Meniere’s Disease: updated resources regarding the current and desirable animal models for MD Mar 31, 2020
- Menière’s disease patients improve specific posturographic parameters following diagnostic intratympanic injection Mar 24, 2020
- Hold the Salt: History of Salt Restriction as a First-line Therapy for Menière’s Disease Mar 19, 2020
- On-Demand and Low Dose Intratympanic Gentamicin for Meniere’s Disease: A Customized Approach Feb 27, 2020
- Bone Mineral Density in Patients Suffering from Ménière’s Disease Feb 21, 2020
- Nutritional Mushroom Treatment in Meniere’s Disease With Coriolus versicolor: A Rationale for Therapeutic Intervention in Neuroinflammation and Antineurodegeneration Dec 31, 2019
- Are viral-infections associated with Ménière’s Disease? Nov 22, 2019
- Chronic cerebrospinal venous insufficiency and menière’s disease: Interventional versus medical therapy Nov 11, 2019
- Conservative Treatment Possibilities of Ménière Disease, Involving Vertigo Diaries Oct 16, 2019
- Long-term outcomes of triple semicircular canal plugging (TSCP) for the treatment of intractable Meniere’s disease (MD) Oct 14, 2019
- A hypothetical proposal for association between migraine and Meniere’s disease Oct 12, 2019
- Food-induced stimulation of the antisecretory factor to improve symptoms in Meniere’s disease: our results Oct 11, 2019
- Expression of aquaporins in inner ear diseases such as Meniere’s disease Oct 8, 2019
- Investigations of the Microvasculature of the Human Macula Utricle in Meniere’s Disease: towards the development of a non-invasive delivery strategy for the treatment of hearing and balance disorders such as MD Oct 4, 2019
- Rare Variants in the OTOG Gene Are a Frequent Cause of Familial Meniere’s Disease Sep 21, 2019
- Solute carrier family 4 member 1 might participate in the pathogenesis of Meniere’s disease in a murine endolymphatic hydrop model Sep 19, 2019
- Rat Model of Ménière’s Attack: Intratympanic Injection of Potassium Chloride Produces Direction-Changing Spontaneous Nystagmus and Hearing Fluctuations Sep 13, 2019
- Menière’s disease treated by grommet insertion Sep 11, 2019
- Efficacy and safety of low-dose intratympanic gentamicin on vertigo attacks in Meniere’s disease Sep 9, 2019
- Intratympanically administered steroid for progressive sensorineural hearing loss in Ménière’s disease Sep 9, 2019
- Correlation between Vestibular Evoked Myogenic Potentials and Disease Progression in Ménière’s Disease Aug 7, 2019
- Structural loss of the distal endolymphatic sac (ES) may contribute to the pathogenesis of Meniere’s disease Jul 23, 2019
- Evolution of Meniere’s Disease: from MD 1.0, via MD 1.5, to MD 2.0 Jul 4, 2019
- Results in caloric test, video head impulse test and inner ear MRI in patients with Ménière’s disease Jul 1, 2019
- Approach to Ménière disease management Jul 1, 2019
- Dissociation of caloric and head impulse tests: a marker of Meniere’s disease Jun 20, 2019
- The Price of Immune Responses and the Role of Vitamin D in the Inner Ear Jun 17, 2019
- Effects of ventilation tube insertion on aural fullness in Ménière’s disease: a review Jun 7, 2019
- The role of ion channels and transporters in the pathophysiology of Ménière’s disease Jun 5, 2019
- Differential Proinflammatory Signature in Vestibular Migraine and Meniere Disease Jun 4, 2019
- Therapeutic Effect of Intratympanic Injection of Dexamethasone plus Hyaluronic Acid on Patients with Meniere’s disease May 18, 2019
- Intratympanic Steroid for Menière’s Disease: A Systematic Review May 16, 2019
- Different medications for the treatment of Ménière’s disease by intratympanic injection: a systematic review and network meta-analysis Apr 26, 2019
- Can verapamil be effective in controlling vertigo and headache attacks in vestibular migraine accompanied with Meniere’s disease? A preliminary study Apr 15, 2019
- The Clinical Benefit of Device Therapy for Meniere’s Disease in Adults: Systematic Review and Meta-Analysis Apr 15, 2019
- Positive pressure therapy for Ménière’s disease Apr 8, 2019
- CASP9 genotype confers gentamicin susceptibility in intratympanic treatment of intractable vertigo caused by Ménière’s disease Mar 25, 2019
- Menière’s Disease and Disorders of the Carbohydrate Metabolism Involving the Inner Ear Feb 15, 2019
- Long-Term Follow-Up of Intratympanic Methylprednisolone Versus Gentamicin in Patients With Unilateral Menière’s Disease Feb 7, 2019
- Peripheral vestibular disorders: an update Feb 1, 2019
- Treatment of Ménière’s disease focusing on vascular risk factors may allow a better control of symptoms and result in a decreased need for ablative procedures Jan 30, 2019
- Meniere’s Disease: A Review of Pathologic Mechanism, Clinical Diagnosis, and New Treatments Jan 15, 2019
- Novel therapy which uses gelatin sponge particles to help deliver high-dose steroids to the inner ear, relieves vertigo, tinnitus, and hearing loss in refractory Ménière’s disease Jan 6, 2019
- Effects of dietary restriction of salt, caffeine and alcohol intake in patients with Ménière’s disease or syndrome Dec 31, 2018
- The pathophysiological mechanism of Ménière’s disease: Has the key been found? Oct 5, 2018
- Long Term Outcomes of Intratympanic Dexamethasone in Intractable Unilateral Meniere’s Disease Jun 24, 2018
- Gene Delivery into the Inner Ear and Its Clinical Implications for Hearing and Balance Jun 3, 2018
Clinical Trials
- Phase 1 Study of SPT-2101 Given as a Single Intratympanic Injection in Subjects with Unilateral Meniere’s Disease Aug 30, 2023
- Modulating Auditory Symptoms and Vertigo of Meniere’s Disease by Non-invasive Mastoid Electric Stimulation Aug 21, 2023
- The CAVA Multicentre Dizziness Trial Aug 9, 2023
- Treating the Symptoms of Vertigo in a Real-world Setting Using the OtoBand Jul 27, 2023
- Assessing the Efficacy of a Serotonin and Norepinephrine Reuptake Inhibitor for Improving Meniere’s Disease Outcomes May 22, 2023
- Safety of APSLXR in Patients Presenting Vertigo of Vestibular Origin or Meniere’s Disease Dec 19, 2020
- Ménière’s Disease Registry (MDR) [Observational] Jul 17, 2020
- Phase 3 Study of OTO-104 in Subjects With Unilateral Meniere’s Disease Jun 17, 2020
- A Study of a Mastoid Device in Subjects With Ménière’s Disease Mar 3, 2020
- Assessing the Efficacy of a Serotonin and Norepinephrine Reuptake Inhibitor for Improving Meniere’s Disease Outcomes Feb 25, 2020
- SPI-1005 for the Treatment of Patients With Meniere’s Disease [Completed] Jun 18, 2019
- Cochlear Implantation During Vestibular Schwannoma Removal or During Labyrinthectomy Surgery for Treatment of Meniere’s Disease Mar 14, 2019
- Transcranial Vibrating System for Improving Vestibular Physical Therapy Jan 7, 2019
Projects
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